diXa: a data infrastructure for chemical safety assessment
نویسندگان
چکیده
MOTIVATION The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. AVAILABILITY AND IMPLEMENTATION http://www.dixa-fp7.eu CONTACT [email protected]; [email protected] SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
منابع مشابه
Methodological Review for Capacity and Punctuality Assessment Procedures
Climate change, congestion, safety, energy consumption and pollution are among the major issues that the European :::union::: and the wider world are facing nowadays. The European Commission is working towards the creation of a Single European Railway Area, encouraging a modal shift towards rail (mainly from road) in order to achieve a more competitive and sustainable European transport syst...
متن کاملAssessment and Monitoring for Railway Tracks Reliability and Safety using Nondestructive Testing Measurement Systems
The deterioration of railway tracks raises great concerns about the integrity of assessments and evaluations of railway tracks currently in service. Integrated inspection strategies coupled with innovations in inspection technology can lead to significant improvements in operational cost efficiency and reliability without the requirement of a fundamental shift in the existing understanding o...
متن کاملA Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure.
When evaluating compound similarity, addressing multiple sources of information to reach conclusions about common pharmaceutical and/or toxicological mechanisms of action is a crucial strategy. In this chapter, we describe a systems biology approach that incorporates analyses of hepatotoxicant data for 33 compounds from three different sources: a chemical structure similarity analysis based on ...
متن کاملارزیابی ریسک شبکه توزیع گاز شهری با استفاده از تحلیل سلسله مراتبی در شهر سنندج
Background and Aims: Natural gas pipeline network is an important part of a city’s infrastructure for energy transmission. As the gas pipeline network becoming vaster and more complex, accident caused by the leak of gas pipeline network occur. Accidents consequences caused by gas pipeline rupture, can directly threatening the safety of persons and properties in the city. Thus, it is neces...
متن کاملA Novel Approach to Evaluate the Road Safety Index: A Case Study in the Roads of East Azerbaijan Province in Iran
Road safety index is an important indicator that has been recently introduced as a useful tool to measure the quality of life in many countries and cities. Road safety index is a complex index and it has at least three main components, including road user behavior, vehicle safety, and road infrastructure effects. Many researchers have selected studying road performance from road safety index pe...
متن کامل